Alkyl Halides
Medchemexpress LLC Bis(2-bromoethyl) ether | 5414-19-7 | 99.77% | 231.92 | 500 G
Bis(2-bromoethyl) ether is an alkyl chain-based PROTAC linker. It can be utilized in the synthesis of PROTACs, which leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs.
- Functions by leveraging the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC 1-Bromotetradecane-d29 | 347841-80-9 | 98.4% | 306.46 | 1 MG
1-Bromotetradecane-d29 is the deuterium labeled 1-Bromotetradecane. It can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes have been incorporated into drug molecules for quantitation during the drug development process. Deuteration has gained attention for its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Spi-112 | 1051387-90-6 | 98.0% | 468.46 | C22H17FN4O5S | 5 MG
SPI-112 is a small-molecule, selective and competitive inhibitor of SHP2 (PTPN11) used for biochemical and cellular research. It inhibits SHP2 and related protein tyrosine phosphatases and is supplied as a solid with guidance for storage and preparation of solution stocks.
- Selective and competitive inhibition of SHP2 for pathway studies.
- Reported IC50 values support biochemical assay characterization.
- High purity solid suitable for preparation of DMSO stocks.
- Available in small milligram quantities and as a prepared solution for convenience.
- Storage recommendations provided to preserve compound stability.
Medchemexpress LLC (7S)-BAY-593 | 2413068-25-2 | 99.61% | 476.53 | 10 MM * 1 ML
(7S)-BAY-593 is the S-enantiomer of BAY-593, an orally active GGTase-I inhibitor that can block YAP1/TAZ signaling in animals and exhibits antitumor activity.
- Inhibits YAP1/TAZ signaling
- Exhibits antitumor activity
- Orally active GGTase-I inhibitor
Medchemexpress LLC RN-1665 | 1803003-65-7 | 99.93% | 513.54 | 50 MG
RN-1665 is an orally active TRPV4 antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively.
- Orally active TRPV4 antagonist.
- Excellent selectivity for related TRP receptors (TRPV1, TRPV3, TRPM8).
- TRPV4 probe for focus screens.
- IC50s: 0.26 μM for hTRPV4, 0.39 μM for rTRPV4.
Medchemexpress LLC 1-Bromododecane | 143-15-7 | 99.2% | 249.24 | 100 G
1-Bromododecane is an organic compound useful in organic synthesis. It is a colorless to light yellow liquid.
- Can be used in organic synthesis
- Available in various sizes
- Recommended storage at room temperature for up to 3 years
- Stable under recommended storage conditions
- Identified uses include laboratory chemicals and manufacture of substances
Medchemexpress LLC 1-Bromotetradecane-d29 | 347841-80-9 | 98.4% | 306.46 | 10 MG
1-Bromotetradecane-d29 is the deuterium labeled 1-Bromotetradecane. It is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Aryl Hydrocarbon Receptor Antibody (YA610) | Predicted: 96 kDa; Observed: 105 kDa | 100 UL
Aryl Hydrocarbon Receptor Antibody (YA610) is a rabbit-derived, non-conjugated IgG monoclonal antibody. It targets the Aryl Hydrocarbon Receptor and is protein A affinity purified. This antibody is for research use only.
- Rabbit-derived
- IgG monoclonal antibody
- Targets Aryl Hydrocarbon Receptor
- Protein A affinity purified
- Non-conjugated
- Reactive with human samples
- Suitable for Western Blot (WB) and Immunocytochemistry/Immunofluorescence (ICC/IF) applications
Medchemexpress LLC 3,5,6-trichloro-2-pyridinol | 6515-38-4 | MFCD00130269 | 99.9% | 198.43 g·mol⁻¹ | C5H2Cl3NO | 1 ML
3,5,6-Trichloro-2-pyridinol is supplied as a 10 mM solution in DMSO (1 mL) for research and analytical use. The compound has CAS 6515-38-4 and a molecular weight of 198.43 g·mol⁻¹. Follow recommended storage guidelines for solution and powder to maintain stability.
- High purity (99.85%).
- Ready-to-use 10 mM solution in DMSO.
- Compact 1 mL vial for small-scale assays.
- Suitable for analytical and research applications.
- Recommended storage: in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC X-376 | 1365267-27-1 | 98.10% | 547.41 | 25 MG
X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM) and exhibits potent anti-tumor activity.
- Effective in inhibiting the growth of various cancer cell lines, including H3122 lung cancer cells (IC50: 77 nM), H2228 lung cancer cells (IC50: 57 nM), and SUDHL-1 lymphoma cells (IC50: 32 nM).
- Also inhibits SY5Y neuroblastoma cells, MKN-45 gastric carcinoma cells, HepG2 cells, and PC-9 lung cancer cell lines.
- Demonstrates substantial bioavailability and moderate half-lives in vivo.
- Significantly delays tumor growth in H3122 xenografts at a dose of 50 mg/kg bid, appearing well-tolerated without affecting mouse weight or causing compound-related toxicity.